Breast cancer is the second most common types of cancer worldwide. Molecular strategies have developed rapidly; however, novel treatments strategies with high efficacy and lower toxicity are still urgently demanded.
Notably, biological networks estimated from microarraydata and functional activity network analysis could be utilized to identify and validate potential targets. In this study, two microarraydata (GSE13477, GSE31192) were firstly selected, and analyzed by multi-functional activity network analysis to generate the core protein-protein-interaction (PPI) network.
Several potential targets were subsequently identified and c-Met and poly (ADP-ribose) polymerase-1 (PARP-1) were manually chosen as the key targets in breast cancer. Furthermore, virtual screening and molecular dynamics (MD) simulations were utilized to recognize novel c-Met/PARP-1 inhibitors in Specs products database.
Three small molecules, namely, ZINC19909930, ZINC20032678 and ZINC13562414 were selected. Additionally, these compounds were synthesized, and two breast cancer cell lines, MDA-MB-231 and MCF-7 cells were used to validate our bioinformatic findings in vitro. MTT assay and Hoechst staining showed that ZINC20032678 significantly induced breast cancer cell death, which was mediated through apoptosis by flow cytometry.
Furthermore, ZINC20032678 was shown to target the active sites of the both targets and recruitment of downstream apoptotic signaling pathways, eventually inducing breast cancer cell apoptosis.
 AES-135 |
|
HY-114483 |
MedChemExpress |
1 mg |
EUR 2380.99 |
|
Description: AES-135, a hydroxamic acid-based pan-HDAC inhibitor, prolongs survival in an orthotopic mouse model of pancreatic cancer. AES-135 inhibits HDAC3, HDAC6, HDAC8, and HDAC11 with IC50s ranging from 190-1100 nM[1]. |
 AES-350 |
|
HY-138831 |
MedChemExpress |
10 mg |
EUR 2023.84 |
|
Description: AES-350 is a potent and orally active HDAC6 inhibitor with an IC50 and a Ki of 0.0244 μM and 0.035 μM, respectively. AES-350 is also against HDAC3, HDAC8 in an enzymatic activity assay with IC50 values of 0.187 μM and 0.245 μM, respectively. AES-350 triggers apoptosis in AML cells through HDAC inhibition and can be used for acute myeloid leukemia (AML) research[1]. |
 AES Peptide |
|
3607P |
ProSci |
0.05 mg |
EUR 197.7 |
|
Description: (CT) AES peptide |
AES Peptide |
|
3609P |
ProSci |
0.05 mg |
EUR 197.7 |
|
Description: (NT) AES peptide |
AES Peptide |
|
42-365P |
ProSci |
0.1 mg |
EUR 405.6 |
|
Description: (NT) AES Peptide |
 AES Protein |
|
20-abx262697 |
Abbexa |
-
Ask for price
-
Ask for price
-
Ask for price
|
|
|
|
AES Peptide |
|
MBS152200-5x005mg |
MyBiosource |
5x0.05mg |
EUR 770 |
AES Peptide |
|
MBS152745-5x005mg |
MyBiosource |
5x0.05mg |
EUR 770 |
AES Peptide |
|
MBS3228155-5x01mg |
MyBiosource |
5x0.1mg |
EUR 730 |
 AES Antibody |
|
3607-002mg |
ProSci |
0.02 mg |
EUR 206.18 |
|
|
|
Description: AES Antibody: Adhesion to extracellular matrix regulates cell survival through both integrin engagement and appropriate cell spreading. Anoikis is the molecular mechanism of apop-tosis induced by integrin detachment. Amino-terminal enhancer of split (AES) is a member of the Groucho/ transducin-like enhancer of split (TLE) family of transcriptional regulators, a group of transcriptional co-repressors that play important roles in neurogenesis, segmentation, and sex determination. AES forms a complex with Bit1 (Bcl-2 inhibitor of transcription 1), a mitochondrial protein that is released into the cytoplasm upon onset of apoptosis. It has been suggested that this complex turns off a survival-promoting gene transcription program controlled by the TLE protein family. Interestingly, apoptosis of cells transfected with AES and Bit1 could be inhibited if the cells were allowed to attach to fibronectin through the alpha5beta1 integrin suggesting that the Bit1-AES pathway contributing to anoikis is regulated by integrins, and in particular, the alpha5beta1 integrin. |
AES Antibody |
|
3607-01mg |
ProSci |
0.1 mg |
EUR 523.7 |
|
|
|
Description: AES Antibody: Adhesion to extracellular matrix regulates cell survival through both integrin engagement and appropriate cell spreading. Anoikis is the molecular mechanism of apop-tosis induced by integrin detachment. Amino-terminal enhancer of split (AES) is a member of the Groucho/ transducin-like enhancer of split (TLE) family of transcriptional regulators, a group of transcriptional co-repressors that play important roles in neurogenesis, segmentation, and sex determination. AES forms a complex with Bit1 (Bcl-2 inhibitor of transcription 1), a mitochondrial protein that is released into the cytoplasm upon onset of apoptosis. It has been suggested that this complex turns off a survival-promoting gene transcription program controlled by the TLE protein family. Interestingly, apoptosis of cells transfected with AES and Bit1 could be inhibited if the cells were allowed to attach to fibronectin through the alpha5beta1 integrin suggesting that the Bit1-AES pathway contributing to anoikis is regulated by integrins, and in particular, the alpha5beta1 integrin. |
AES Antibody |
|
3609-002mg |
ProSci |
0.02 mg |
EUR 206.18 |
|
|
|
Description: AES Antibody: Adhesion to extracellular matrix regulates cell survival through both integrin engagement and appropriate cell spreading. Anoikis is the molecular mechanism of apop-tosis induced by integrin detachment. Amino-terminal enhancer of split (AES) is a member of the Groucho/ transducin-like enhancer of split (TLE) family of transcriptional regulators, a group of transcriptional co-repressors that play important roles in neurogenesis, segmentation, and sex determination. AES forms a complex with Bit1 (Bcl-2 inhibitor of transcription 1), a mitochondrial protein that is released into the cytoplasm upon onset of apoptosis. It has been suggested that this complex turns off a survival-promoting gene transcription program controlled by the TLE protein family. Interestingly, apoptosis of cells transfected with AES and Bit1 could be inhibited if the cells were allowed to attach to fibronectin through the alpha5beta1 integrin suggesting that the Bit1-AES pathway contributing to anoikis is regulated by integrins, and in particular, the alpha5beta1 integrin. |
AES Antibody |
|
3609-01mg |
ProSci |
0.1 mg |
EUR 523.7 |
|
|
|
Description: AES Antibody: Adhesion to extracellular matrix regulates cell survival through both integrin engagement and appropriate cell spreading. Anoikis is the molecular mechanism of apop-tosis induced by integrin detachment. Amino-terminal enhancer of split (AES) is a member of the Groucho/ transducin-like enhancer of split (TLE) family of transcriptional regulators, a group of transcriptional co-repressors that play important roles in neurogenesis, segmentation, and sex determination. AES forms a complex with Bit1 (Bcl-2 inhibitor of transcription 1), a mitochondrial protein that is released into the cytoplasm upon onset of apoptosis. It has been suggested that this complex turns off a survival-promoting gene transcription program controlled by the TLE protein family. Interestingly, apoptosis of cells transfected with AES and Bit1 could be inhibited if the cells were allowed to attach to fibronectin through the alpha5beta1 integrin suggesting that the Bit1-AES pathway contributing to anoikis is regulated by integrins, and in particular, the alpha5beta1 integrin. |
AES Antibody |
|
36095 |
SAB |
100ul |
EUR 319 |
AES Antibody |
|
36095-100ul |
SAB |
100ul |
EUR 302.4 |
AES Antibody |
|
24349 |
SAB |
100ul |
EUR 479 |
AES Antibody |
|
24349-100ul |
SAB |
100ul |
EUR 468 |
AES Antibody |
|
24350-100ul |
SAB |
100ul |
EUR 468 |
AES Antibody |
|
1-CSB-PA001405ESR2HU |
Cusabio |
-
Ask for price
-
Ask for price
|
|
|
|
|
Description: A polyclonal antibody against AES. Recognizes AES from Human. This antibody is Unconjugated. Tested in the following application: ELISA, IHC; Recommended dilution: IHC:1:20-1:200 |
 aes Antibody |
|
CSB-PA855595XA01EOD-02mg |
Cusabio |
0.2mg |
Ask for price |
|
|
|
Description: Recombinant Escherichia coli O157:H7 aes protein |
aes Antibody |
|
CSB-PA855595XA01EOD-10mg |
Cusabio |
10mg |
Ask for price |
|
|
|
Description: Recombinant Escherichia coli O157:H7 aes protein |
aes Antibody |
|
CSB-PA630124XA01EGW-02mg |
Cusabio |
0.2mg |
Ask for price |
|
|
|
Description: Recombinant Escherichia coli (strain UTI89 / UPEC) aes protein |
aes Antibody |
|
CSB-PA630124XA01EGW-10mg |
Cusabio |
10mg |
Ask for price |
|
|
|
Description: Recombinant Escherichia coli (strain UTI89 / UPEC) aes protein |
aes Antibody |
|
CSB-PA605647XA01EGY-02mg |
Cusabio |
0.2mg |
Ask for price |
|
|
|
Description: Recombinant Escherichia coli O6:K15:H31 (strain 536 / UPEC) aes protein |
aes Antibody |
|
CSB-PA605647XA01EGY-10mg |
Cusabio |
10mg |
Ask for price |
|
|
|
Description: Recombinant Escherichia coli O6:K15:H31 (strain 536 / UPEC) aes protein |
aes Antibody |
|
CSB-PA536880XA01ENP-02mg |
Cusabio |
0.2mg |
Ask for price |
|
|
|
Description: Recombinant Escherichia coli (strain ATCC 8739 / DSM 1576 / Crooks) aes protein |
aes Antibody |
|
CSB-PA536880XA01ENP-10mg |
Cusabio |
10mg |
Ask for price |
|
|
|
Description: Recombinant Escherichia coli (strain ATCC 8739 / DSM 1576 / Crooks) aes protein |
aes Antibody |
|
CSB-PA540718XA01ENX-02mg |
Cusabio |
0.2mg |
Ask for price |
|
|
|
Description: Recombinant Escherichia coli (strain SMS-3-5 / SECEC) aes protein |
aes Antibody |
|
CSB-PA540718XA01ENX-10mg |
Cusabio |
10mg |
Ask for price |
|
|
|
Description: Recombinant Escherichia coli (strain SMS-3-5 / SECEC) aes protein |
AES Antibody |
|
1-CSB-PA551903 |
Cusabio |
-
Ask for price
-
Ask for price
|
|
|
|
|
Description: A polyclonal antibody against AES. Recognizes AES from Human. This antibody is Unconjugated. Tested in the following application: ELISA, IHC;ELISA:1:2000-1:5000, IHC:1:25-1:100 |
aes Antibody |
|
CSB-PA487112XA01EOG-02mg |
Cusabio |
0.2mg |
Ask for price |
|
|
|
Description: Recombinant Escherichia coli O17:K52:H18 (strain UMN026 / ExPEC) aes protein |
aes Antibody |
|
CSB-PA487112XA01EOG-10mg |
Cusabio |
10mg |
Ask for price |
|
|
|
Description: Recombinant Escherichia coli O17:K52:H18 (strain UMN026 / ExPEC) aes protein |
aes Antibody |
|
CSB-PA509255XA01ENU-02mg |
Cusabio |
0.2mg |
Ask for price |
|
|
|
Description: Recombinant Escherichia coli (strain K12 / MC4100 / BW2952) aes protein |
aes Antibody |
|
CSB-PA509255XA01ENU-10mg |
Cusabio |
10mg |
Ask for price |
|
|
|
Description: Recombinant Escherichia coli (strain K12 / MC4100 / BW2952) aes protein |
aes Antibody |
|
CSB-PA484782XA01EOB-02mg |
Cusabio |
0.2mg |
Ask for price |
|
|
|
Description: Recombinant Escherichia coli O127:H6 (strain E2348/69 / EPEC) aes protein |
aes Antibody |
|
CSB-PA484782XA01EOB-10mg |
Cusabio |
10mg |
Ask for price |
|
|
|
Description: Recombinant Escherichia coli O127:H6 (strain E2348/69 / EPEC) aes protein |
aes Antibody |
|
CSB-PA484382XA01EOK-02mg |
Cusabio |
0.2mg |
Ask for price |
|
|
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Description: Recombinant Escherichia coli O45:K1 (strain S88 / ExPEC) aes protein |
aes Antibody |
|
CSB-PA484382XA01EOK-10mg |
Cusabio |
10mg |
Ask for price |
|
|
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Description: Recombinant Escherichia coli O45:K1 (strain S88 / ExPEC) aes protein |
aes Antibody |
|
CSB-PA335004XA01ENV-02mg |
Cusabio |
0.2mg |
Ask for price |
|
|
|
Description: Recombinant Escherichia coli (strain K12) aes protein |
aes Antibody |
|
CSB-PA335004XA01ENV-10mg |
Cusabio |
10mg |
Ask for price |
|
|
|
Description: Recombinant Escherichia coli (strain K12) aes protein |
aes Antibody |
|
CSB-PA800935XA01SZB-02mg |
Cusabio |
0.2mg |
Ask for price |
|
|
|
Description: Recombinant Shigella flexneri aes protein |
aes Antibody |
|
CSB-PA800935XA01SZB-10mg |
Cusabio |
10mg |
Ask for price |
|
|
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Description: Recombinant Shigella flexneri aes protein |
aes Antibody |
|
CSB-PA817939XA01FQR-02mg |
Cusabio |
0.2mg |
Ask for price |
|
|
|
Description: Recombinant Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC) aes protein |
aes Antibody |
|
CSB-PA817939XA01FQR-10mg |
Cusabio |
10mg |
Ask for price |
|
|
|
Description: Recombinant Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC) aes protein |
aes Antibody |
|
CSB-PA371727XA01EJE-02mg |
Cusabio |
0.2mg |
Ask for price |
|
|
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Description: Recombinant Escherichia coli O1:K1 / APEC aes protein |
aes Antibody |
|
CSB-PA371727XA01EJE-10mg |
Cusabio |
10mg |
Ask for price |
|
|
|
Description: Recombinant Escherichia coli O1:K1 / APEC aes protein |
aes Antibody |
|
CSB-PA421002XA01EJF-02mg |
Cusabio |
0.2mg |
Ask for price |
|
|
|
Description: Recombinant Escherichia coli O9:H4 (strain HS) aes protein |
aes Antibody |
|
CSB-PA421002XA01EJF-10mg |
Cusabio |
10mg |
Ask for price |
|
|
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Description: Recombinant Escherichia coli O9:H4 (strain HS) aes protein |
aes Antibody |
|
CSB-PA421925XA01EJD-02mg |
Cusabio |
0.2mg |
Ask for price |
|
|
|
Description: Recombinant Escherichia coli O139:H28 (strain E24377A / ETEC) aes protein |
aes Antibody |
|
CSB-PA421925XA01EJD-10mg |
Cusabio |
10mg |
Ask for price |
|
|
|
Description: Recombinant Escherichia coli O139:H28 (strain E24377A / ETEC) aes protein |
aes Antibody |
|
CSB-PA453927XA01ENT-02mg |
Cusabio |
0.2mg |
Ask for price |
|
|
|
Description: Recombinant Escherichia coli (strain K12 / DH10B) aes protein |
aes Antibody |
|
CSB-PA453927XA01ENT-10mg |
Cusabio |
10mg |
Ask for price |
|
|
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Description: Recombinant Escherichia coli (strain K12 / DH10B) aes protein |
aes Antibody |
|
CSB-PA471527XA01EOE-02mg |
Cusabio |
0.2mg |
Ask for price |
|
|
|
Description: Recombinant Escherichia coli O157:H7 (strain EC4115 / EHEC) aes protein |
aes Antibody |
|
CSB-PA471527XA01EOE-10mg |
Cusabio |
10mg |
Ask for price |
|
|
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Description: Recombinant Escherichia coli O157:H7 (strain EC4115 / EHEC) aes protein |
aes Antibody |
|
CSB-PA475813XA01ENW-02mg |
Cusabio |
0.2mg |
Ask for price |
|
|
|
Description: Recombinant Escherichia coli (strain SE11) aes protein |
aes Antibody |
|
CSB-PA475813XA01ENW-10mg |
Cusabio |
10mg |
Ask for price |
|
|
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Description: Recombinant Escherichia coli (strain SE11) aes protein |
aes Antibody |
|
CSB-PA482329XA01ENM-02mg |
Cusabio |
0.2mg |
Ask for price |
|
|
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Description: Recombinant Escherichia coli (strain 55989 / EAEC) aes protein |
aes Antibody |
|
CSB-PA482329XA01ENM-10mg |
Cusabio |
10mg |
Ask for price |
|
|
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Description: Recombinant Escherichia coli (strain 55989 / EAEC) aes protein |
aes Antibody |
|
CSB-PA482548XA01EOO-02mg |
Cusabio |
0.2mg |
Ask for price |
|
|
|
Description: Recombinant Escherichia coli O8 (strain IAI1) aes protein |
aes Antibody |
|
CSB-PA482548XA01EOO-10mg |
Cusabio |
10mg |
Ask for price |
|
|
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Description: Recombinant Escherichia coli O8 (strain IAI1) aes protein |
aes Antibody |
|
CSB-PA482712XA01EOP-02mg |
Cusabio |
0.2mg |
Ask for price |
|
|
|
Description: Recombinant Escherichia coli O81 (strain ED1a) aes protein |
aes Antibody |
|
CSB-PA482712XA01EOP-10mg |
Cusabio |
10mg |
Ask for price |
|
|
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Description: Recombinant Escherichia coli O81 (strain ED1a) aes protein |
aes Antibody |
|
CSB-PA482898XA01EON-02mg |
Cusabio |
0.2mg |
Ask for price |
|
|
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Description: Recombinant Escherichia coli O7:K1 (strain IAI39 / ExPEC) aes protein |
aes Antibody |
|
CSB-PA482898XA01EON-10mg |
Cusabio |
10mg |
Ask for price |
|
|
|
Description: Recombinant Escherichia coli O7:K1 (strain IAI39 / ExPEC) aes protein |
AES Antibody |
|
C42512-100ul |
Assay Biotech |
100μl |
EUR 217 |
|
Description: AES Rabbit Polyclonal Antibody |
AES Antibody |
|
C42512-50ul |
Assay Biotech |
50μl |
EUR 143.5 |
|
Description: AES Rabbit Polyclonal Antibody |
AES Antibody |
|
1-CSB-PA973928 |
Cusabio |
-
Ask for price
-
Ask for price
|
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Description: A polyclonal antibody against AES. Recognizes AES from Human. This antibody is Unconjugated. Tested in the following application: ELISA, IHC;ELISA:1:2000-1:5000, IHC:1:25-1:100 |
AES Antibody |
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E036095 |
EnoGene |
100μg/100μl |
EUR 255 |
|
Description: Available in various conjugation types. |
AES Antibody |
|
E97874 |
EnoGene |
100ul |
EUR 255 |
|
Description: Available in various conjugation types. |
AES Antibody |
|
MBS150869-5x01mg |
MyBiosource |
5x0.1mg |
EUR 1965 |
AES Antibody |
|
MBS150968-5x01mg |
MyBiosource |
5x0.1mg |
EUR 1965 |
AES Antibody |
|
MBS1491947-005mL |
MyBiosource |
0.05mL |
EUR 190 |
AES Antibody |
|
MBS1491947-5x01mL |
MyBiosource |
5x0.1mL |
EUR 1205 |
AES Antibody |
|
MBS7124696-005mL |
MyBiosource |
0.05mL |
EUR 190 |
AES Antibody |
|
MBS7124696-5x01mL |
MyBiosource |
5x0.1mL |
EUR 1205 |
AES Antibody |
|
MBS7124697-005mL |
MyBiosource |
0.05mL |
EUR 190 |
AES Antibody |
|
MBS7124697-5x01mL |
MyBiosource |
5x0.1mL |
EUR 1205 |
AES Antibody |
|
MBS9403841-5x01mL |
MyBiosource |
5x0.1mL |
EUR 1230 |
AES Antibody |
|
MBS9407608-5x01mL |
MyBiosource |
5x0.1mL |
EUR 2075 |
AES Antibody |
|
MBS9412814-5x01mL |
MyBiosource |
5x0.1mL |
EUR 2075 |
 Rat AES siRNA |
|
20-abx906940 |
Abbexa |
-
Ask for price
-
Ask for price
|
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) AES siRNA (Rat) |
|
MBS8212765-15nmol |
MyBiosource |
15nmol |
EUR 405 |
AES siRNA (Rat) |
|
MBS8212765-30nmol |
MyBiosource |
30nmol |
EUR 565 |
AES siRNA (Rat) |
|
MBS8212765-5x30nmol |
MyBiosource |
5x30nmol |
EUR 2450 |
 AES Rabbit pAb |
|
A7874 |
Abclonal |
50μL |
EUR 152.33 |
AES Rabbit pAb |
|
A7874-100ul |
Abclonal |
100 ul |
EUR 369.6 |
AES Rabbit pAb |
|
A7874-200ul |
Abclonal |
200 ul |
EUR 550.8 |
AES Rabbit pAb |
|
A7874-20ul |
Abclonal |
20 ul |
EUR 219.6 |
AES Rabbit pAb |
|
A7874-50ul |
Abclonal |
50 ul |
EUR 267.6 |
AES Rabbit pAb |
|
E2507874 |
EnoGene |
100ul |
EUR 225 |
|
Description: Available in various conjugation types. |
AES Rabbit pAb |
|
E45R27774N |
EnoGene |
50 ul |
EUR 297.75 |
AES Rabbit pAb |
|
MBS8547098-01mL |
MyBiosource |
0.1mL |
EUR 305 |
AES Rabbit pAb |
|
MBS8547098-01mLAF405L |
MyBiosource |
0.1mL(AF405L) |
EUR 565 |
AES Rabbit pAb |
|
MBS8547098-01mLAF405S |
MyBiosource |
0.1mL(AF405S) |
EUR 565 |
AES Rabbit pAb |
|
MBS8547098-01mLAF610 |
MyBiosource |
0.1mL(AF610) |
EUR 565 |
AES Rabbit pAb |
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MBS8547098-01mLAF635 |
MyBiosource |
0.1mL(AF635) |
EUR 565 |
 Mouse AES siRNA |
|
20-abx906941 |
Abbexa |
-
Ask for price
-
Ask for price
|
|
|
|
 Human AES siRNA |
|
20-abx900213 |
Abbexa |
-
Ask for price
-
Ask for price
|
|
|
|
) AES siRNA (Mouse) |
|
MBS8200177-15nmol |
MyBiosource |
15nmol |
EUR 405 |
AES siRNA (Mouse) |
|
MBS8200177-30nmol |
MyBiosource |
30nmol |
EUR 565 |
AES siRNA (Mouse) |
|
MBS8200177-5x30nmol |
MyBiosource |
5x30nmol |
EUR 2450 |
) AES siRNA (Human) |
|
MBS8223619-15nmol |
MyBiosource |
15nmol |
EUR 405 |
AES siRNA (Human) |
|
MBS8223619-30nmol |
MyBiosource |
30nmol |
EUR 565 |
AES siRNA (Human) |
|
MBS8223619-5x30nmol |
MyBiosource |
5x30nmol |
EUR 2450 |
 AES Immunizing Peptide |
|
MBS427550-01mg |
MyBiosource |
0.1mg |
EUR 225 |
 AES Polyclonal Antibody |
|
A73477 |
EpiGentek |
-
Ask for price
-
Ask for price
|
|
AES Polyclonal Antibody |
|
ABP57720-003ml |
Abbkine |
0.03ml |
EUR 189.6 |
|
|
|
Description: A polyclonal antibody for detection of AES from Human, Mouse, Rat. This AES antibody is for WB, ELISA. It is affinity-purified from rabbit serum by affinity-chromatography using the specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from part region of human AES protein |
AES Polyclonal Antibody |
|
ABP57720-01ml |
Abbkine |
0.1ml |
EUR 346.8 |
|
|
|
Description: A polyclonal antibody for detection of AES from Human, Mouse, Rat. This AES antibody is for WB, ELISA. It is affinity-purified from rabbit serum by affinity-chromatography using the specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from part region of human AES protein |
AES Polyclonal Antibody |
|
ABP57720-02ml |
Abbkine |
0.2ml |
EUR 496.8 |
|
|
|
Description: A polyclonal antibody for detection of AES from Human, Mouse, Rat. This AES antibody is for WB, ELISA. It is affinity-purified from rabbit serum by affinity-chromatography using the specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from part region of human AES protein |
 AES polyclonal antibody |
|
BS70969 |
Bioworld Biotech |
50 ul |
EUR 358 |
|
|
|
Description: 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2 |
AES Polyclonal Antibody |
|
E-AB-62616-120uL |
Elabscience Biotech |
120uL |
EUR 320 |
|
|
|
Description: Unconjugated |
AES Polyclonal Antibody |
|
E-AB-62616-200uL |
Elabscience Biotech |
200uL |
EUR 530 |
|
|
|
Description: Unconjugated |
AES Polyclonal Antibody |
|
E-AB-62616-60uL |
Elabscience Biotech |
60uL |
EUR 200 |
|
|
|
Description: Unconjugated |
AES Polyclonal Antibody |
|
E-AB-62616-each |
Elabscience Biotech |
each |
Ask for price |
|
|
|
Description: Unconjugated |
 Polyclonal AES Antibody |
|
AMM08746G |
Leading Biology |
0.1 mg |
EUR 790.8 |
|
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human AES . This antibody is tested and proven to work in the following applications: |
Polyclonal AES Antibody |
|
AMM08747G |
Leading Biology |
0.1 mg |
EUR 790.8 |
|
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human AES . This antibody is tested and proven to work in the following applications: |
AES Polyclonal Antibody |
|
BT-AP14139-100ul |
Jiaxing Korain Biotech Ltd (BT Labs) |
100ul |
Ask for price |
|
|
|
Description: The protein encoded by this gene is similar in sequence to the amino terminus of Drosophila enhancer of split groucho| a protein involved in neurogenesis during embryonic development. The encoded protein| which belongs to the groucho/TLE family of proteins| can function as a homooligomer or as a heteroologimer with other family members to dominantly repress the expression of other family member genes. Three transcript variants encoding different isoforms have been found for this gene. |
AES Polyclonal Antibody |
|
BT-AP14139-20ul |
Jiaxing Korain Biotech Ltd (BT Labs) |
20ul |
Ask for price |
|
|
|
Description: The protein encoded by this gene is similar in sequence to the amino terminus of Drosophila enhancer of split groucho| a protein involved in neurogenesis during embryonic development. The encoded protein| which belongs to the groucho/TLE family of proteins| can function as a homooligomer or as a heteroologimer with other family members to dominantly repress the expression of other family member genes. Three transcript variants encoding different isoforms have been found for this gene. |
AES Polyclonal Antibody |
|
BT-AP14139-50ul |
Jiaxing Korain Biotech Ltd (BT Labs) |
50ul |
Ask for price |
|
|
|
Description: The protein encoded by this gene is similar in sequence to the amino terminus of Drosophila enhancer of split groucho| a protein involved in neurogenesis during embryonic development. The encoded protein| which belongs to the groucho/TLE family of proteins| can function as a homooligomer or as a heteroologimer with other family members to dominantly repress the expression of other family member genes. Three transcript variants encoding different isoforms have been found for this gene. |
 AES Conjugated Antibody |
|
C36095 |
SAB |
100ul |
EUR 476.4 |
AES Polyclonal Antibody |
|
E11-202046 |
EnoGene |
100ug/100ul |
EUR 225 |
|
Description: Available in various conjugation types. |
AES Polyclonal Antibody |
|
JOT-AP14139-100ul |
Jotbody |
100ul |
EUR 220 |
|
|
AES Polyclonal Antibody |
|
JOT-AP14139-50ul |
Jotbody |
50ul |
EUR 144 |
|
|
AES Polyclonal Antibody |
|
E44H09653 |
EnoGene |
100ul |
EUR 255 |
|
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody |
AES Polyclonal Antibody |
|
MBS2541137-006mL |
MyBiosource |
0.06mL |
EUR 190 |
AES Polyclonal Antibody |
|
MBS2541137-012mL |
MyBiosource |
0.12mL |
EUR 265 |
AES Polyclonal Antibody |
|
MBS2541137-02mL |
MyBiosource |
0.2mL |
EUR 415 |
AES Polyclonal Antibody |
|
MBS2541137-5x02mL |
MyBiosource |
5x0.2mL |
EUR 1835 |
AES Polyclonal Antibody |
|
MBS2527642-002mL |
MyBiosource |
0.02mL |
EUR 140 |
AES Polyclonal Antibody |
|
MBS2527642-006mL |
MyBiosource |
0.06mL |
EUR 180 |
AES Polyclonal Antibody |
|
MBS2527642-012mL |
MyBiosource |
0.12mL |
EUR 260 |
AES Polyclonal Antibody |
|
MBS2527642-02mL |
MyBiosource |
0.2mL |
EUR 405 |
AES Polyclonal Antibody |
|
MBS2520981-002mL |
MyBiosource |
0.02mL |
EUR 140 |
AES Polyclonal Antibody |
|
MBS2520981-006mL |
MyBiosource |
0.06mL |
EUR 180 |
AES Polyclonal Antibody |
|
MBS2520981-012mL |
MyBiosource |
0.12mL |
EUR 260 |
AES Polyclonal Antibody |
|
MBS2520981-02mL |
MyBiosource |
0.2mL |
EUR 405 |
AES Polyclonal Antibody |
|
MBS9128149-002mL |
MyBiosource |
0.02mL |
EUR 200 |
AES Polyclonal Antibody |
|
MBS9128149-005mL |
MyBiosource |
0.05mL |
EUR 255 |
AES Polyclonal Antibody |
|
MBS9128149-01mL |
MyBiosource |
0.1mL |
EUR 345 |
AES Polyclonal Antibody |
|
MBS9128149-02mL |
MyBiosource |
0.2mL |
EUR 545 |
AES Polyclonal Antibody |
|
MBS9128149-5x02mL |
MyBiosource |
5x0.2mL |
EUR 2265 |
AES Polyclonal Antibody |
|
MBS8531400-01mg |
MyBiosource |
0.1mg |
EUR 305 |
AES Polyclonal Antibody |
|
MBS8531400-01mLAF405L |
MyBiosource |
0.1mL(AF405L) |
EUR 465 |
AES Polyclonal Antibody |
|
MBS8531400-01mLAF405S |
MyBiosource |
0.1mL(AF405S) |
EUR 465 |
AES Polyclonal Antibody |
|
MBS8531400-01mLAF610 |
MyBiosource |
0.1mL(AF610) |
EUR 465 |
AES Polyclonal Antibody |
|
MBS8531400-01mLAF635 |
MyBiosource |
0.1mL(AF635) |
EUR 465 |
AES Conjugated Antibody |
|
MBS9446558-01mLAF350 |
MyBiosource |
0.1mL(AF350) |
EUR 480 |
AES Conjugated Antibody |
|
MBS9446558-01mLAF405 |
MyBiosource |
0.1mL(AF405) |
EUR 480 |
AES Conjugated Antibody |
|
MBS9446558-01mLAF488 |
MyBiosource |
0.1mL(AF488) |
EUR 480 |
AES Conjugated Antibody |
|
MBS9446558-01mLAF555 |
MyBiosource |
0.1mL(AF555) |
EUR 480 |
Collectively, our findings not only offer systems biology approaches based drug target identification, but also provide the new clues for developing novel inhibitors for future breast cancer research.
