Systems biology approaches based discovery of a small molecule inhibitor targeting both c-Met/PARP-1 and inducing cell death in breast cancer.

Breast cancer is the second most common types of cancer worldwide. Molecular strategies have developed rapidly; however, novel treatments strategies with high efficacy and lower toxicity are still urgently demanded.

Notably, biological networks estimated from microarraydata and functional activity network analysis could be utilized to identify and validate potential targets. In this study, two microarraydata (GSE13477, GSE31192) were firstly selected, and analyzed by multi-functional activity network analysis to generate the core protein-protein-interaction (PPI) network.

Several potential targets were subsequently identified and c-Met and poly (ADP-ribose) polymerase-1 (PARP-1) were manually chosen as the key targets in breast cancer. Furthermore, virtual screening and molecular dynamics (MD) simulations were utilized to recognize novel c-Met/PARP-1 inhibitors in Specs products database.

Three small molecules, namely, ZINC19909930, ZINC20032678 and ZINC13562414 were selected. Additionally, these compounds were synthesized, and two breast cancer cell lines, MDA-MB-231 and MCF-7 cells were used to validate our bioinformatic findings in vitro. MTT assay and Hoechst staining showed that ZINC20032678 significantly induced breast cancer cell death, which was mediated through apoptosis by flow cytometry.

Furthermore, ZINC20032678 was shown to target the active sites of the both targets and recruitment of downstream apoptotic signaling pathways, eventually inducing breast cancer cell apoptosis.

AES-350
T9041-1g 1g Ask for price
Description: AES-350

AES-350
T9041-1mg 1mg Ask for price
Description: AES-350

AES-350
T9041-50mg 50mg Ask for price
Description: AES-350

AES-350
T9041-5mg 5mg Ask for price
Description: AES-350

AES siRNA
20-abx906940
  • EUR 661.20
  • EUR 878.40
  • 15 nmol
  • 30 nmol

AES siRNA
20-abx906941
  • EUR 661.20
  • EUR 878.40
  • 15 nmol
  • 30 nmol

AES siRNA
20-abx900213
  • EUR 661.20
  • EUR 878.40
  • 15 nmol
  • 30 nmol

AES Protein
20-abx262697
  • EUR 393.60
  • EUR 7676.40
  • EUR 276.00
  • 10 ug
  • 1 mg
  • 2 µg

AES Peptide
42-365P 0.1 mg
EUR 405.6
Description: (NT) AES Peptide

AES Peptide
3607P 0.05 mg
EUR 197.7
Description: (CT) AES peptide

AES Peptide
3609P 0.05 mg
EUR 197.7
Description: (NT) AES peptide

AES Antibody
24349-100ul 100ul
EUR 468

AES Antibody
24350-100ul 100ul
EUR 468

AES antibody
70R-1059 100 ug
EUR 452.4
Description: Rabbit polyclonal AES antibody raised against the C terminal of AES

AES antibody
70R-7912 50 ug
EUR 560.4
Description: Affinity purified rabbit polyclonal AES antibody

AES Antibody
3607-002mg 0.02 mg
EUR 206.18
Description: AES Antibody: Adhesion to extracellular matrix regulates cell survival through both integrin engagement and appropriate cell spreading. Anoikis is the molecular mechanism of apop-tosis induced by integrin detachment. Amino-terminal enhancer of split (AES) is a member of the Groucho/ transducin-like enhancer of split (TLE) family of transcriptional regulators, a group of transcriptional co-repressors that play important roles in neurogenesis, segmentation, and sex determination. AES forms a complex with Bit1 (Bcl-2 inhibitor of transcription 1), a mitochondrial protein that is released into the cytoplasm upon onset of apoptosis. It has been suggested that this complex turns off a survival-promoting gene transcription program controlled by the TLE protein family. Interestingly, apoptosis of cells transfected with AES and Bit1 could be inhibited if the cells were allowed to attach to fibronectin through the alpha5beta1 integrin suggesting that the Bit1-AES pathway contributing to anoikis is regulated by integrins, and in particular, the alpha5beta1 integrin.

AES Antibody
3607-01mg 0.1 mg
EUR 523.7
Description: AES Antibody: Adhesion to extracellular matrix regulates cell survival through both integrin engagement and appropriate cell spreading. Anoikis is the molecular mechanism of apop-tosis induced by integrin detachment. Amino-terminal enhancer of split (AES) is a member of the Groucho/ transducin-like enhancer of split (TLE) family of transcriptional regulators, a group of transcriptional co-repressors that play important roles in neurogenesis, segmentation, and sex determination. AES forms a complex with Bit1 (Bcl-2 inhibitor of transcription 1), a mitochondrial protein that is released into the cytoplasm upon onset of apoptosis. It has been suggested that this complex turns off a survival-promoting gene transcription program controlled by the TLE protein family. Interestingly, apoptosis of cells transfected with AES and Bit1 could be inhibited if the cells were allowed to attach to fibronectin through the alpha5beta1 integrin suggesting that the Bit1-AES pathway contributing to anoikis is regulated by integrins, and in particular, the alpha5beta1 integrin.

AES Antibody
3609-002mg 0.02 mg
EUR 206.18
Description: AES Antibody: Adhesion to extracellular matrix regulates cell survival through both integrin engagement and appropriate cell spreading. Anoikis is the molecular mechanism of apop-tosis induced by integrin detachment. Amino-terminal enhancer of split (AES) is a member of the Groucho/ transducin-like enhancer of split (TLE) family of transcriptional regulators, a group of transcriptional co-repressors that play important roles in neurogenesis, segmentation, and sex determination. AES forms a complex with Bit1 (Bcl-2 inhibitor of transcription 1), a mitochondrial protein that is released into the cytoplasm upon onset of apoptosis. It has been suggested that this complex turns off a survival-promoting gene transcription program controlled by the TLE protein family. Interestingly, apoptosis of cells transfected with AES and Bit1 could be inhibited if the cells were allowed to attach to fibronectin through the alpha5beta1 integrin suggesting that the Bit1-AES pathway contributing to anoikis is regulated by integrins, and in particular, the alpha5beta1 integrin.

AES Antibody
3609-01mg 0.1 mg
EUR 523.7
Description: AES Antibody: Adhesion to extracellular matrix regulates cell survival through both integrin engagement and appropriate cell spreading. Anoikis is the molecular mechanism of apop-tosis induced by integrin detachment. Amino-terminal enhancer of split (AES) is a member of the Groucho/ transducin-like enhancer of split (TLE) family of transcriptional regulators, a group of transcriptional co-repressors that play important roles in neurogenesis, segmentation, and sex determination. AES forms a complex with Bit1 (Bcl-2 inhibitor of transcription 1), a mitochondrial protein that is released into the cytoplasm upon onset of apoptosis. It has been suggested that this complex turns off a survival-promoting gene transcription program controlled by the TLE protein family. Interestingly, apoptosis of cells transfected with AES and Bit1 could be inhibited if the cells were allowed to attach to fibronectin through the alpha5beta1 integrin suggesting that the Bit1-AES pathway contributing to anoikis is regulated by integrins, and in particular, the alpha5beta1 integrin.

AES Antibody
36095-100ul 100ul
EUR 302.4

AES Antibody
1-CSB-PA973928
  • EUR 380.40
  • EUR 292.80
  • 100ul
  • 50ul
Description: A polyclonal antibody against AES. Recognizes AES from Human. This antibody is Unconjugated. Tested in the following application: ELISA, IHC;ELISA:1:2000-1:5000, IHC:1:25-1:100

AES Antibody
1-CSB-PA551903
  • EUR 380.40
  • EUR 292.80
  • 100ul
  • 50ul
Description: A polyclonal antibody against AES. Recognizes AES from Human. This antibody is Unconjugated. Tested in the following application: ELISA, IHC;ELISA:1:2000-1:5000, IHC:1:25-1:100

AES Antibody
1-CSB-PA001405ESR2HU
  • EUR 266.40
  • EUR 402.00
  • 100ul
  • 50ul
Description: A polyclonal antibody against AES. Recognizes AES from Human. This antibody is Unconjugated. Tested in the following application: ELISA, IHC; Recommended dilution: IHC:1:20-1:200

AES Antibody
R35917-100UG 100 ug
EUR 339.15
Description: Additional name(s) for this target protein: Amino-terminal enhancer of split, AES-1

AES Antibody
E036095 100μg/100μl
EUR 255
Description: Available in various conjugation types.

AES Antibody
E97874 100ul
EUR 255
Description: Available in various conjugation types.

AES Antibody
36095 100ul
EUR 319

AES Antibody
24349 100ul
EUR 479

AES Antibody
24350 100ul
EUR 479

AES Rabbit pAb
A7874-100ul 100 ul
EUR 369.6

AES Rabbit pAb
A7874-200ul 200 ul
EUR 550.8

AES Rabbit pAb
A7874-20ul 20 ul
EUR 219.6

AES Rabbit pAb
A7874-50ul 50 ul
EUR 267.6

AES Rabbit pAb
E2507874 100ul
EUR 225
Description: Available in various conjugation types.

AES Blocking Peptide
33R-3414 100 ug
EUR 216
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of AES antibody, catalog no. 70R-1059

AES Blocking Peptide
33R-3767 100 ug
EUR 216
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of AES antibody, catalog no. 70R-7912

Polyclonal AES Antibody
AMM08746G 0.1 mg
EUR 790.8
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human AES . This antibody is tested and proven to work in the following applications:

Polyclonal AES Antibody
AMM08747G 0.1 mg
EUR 790.8
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human AES . This antibody is tested and proven to work in the following applications:

AES Conjugated Antibody
C36095 100ul
EUR 476.4

AES Polyclonal Antibody
A73477
  • EUR 377.30
  • EUR 577.50
  • 50 ul
  • 100 ul

AES Polyclonal Antibody
ABP57720-003ml 0.03ml
EUR 189.6
Description: A polyclonal antibody for detection of AES from Human, Mouse, Rat. This AES antibody is for WB, ELISA. It is affinity-purified from rabbit serum by affinity-chromatography using the specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from part region of human AES protein

AES Polyclonal Antibody
ABP57720-01ml 0.1ml
EUR 346.8
Description: A polyclonal antibody for detection of AES from Human, Mouse, Rat. This AES antibody is for WB, ELISA. It is affinity-purified from rabbit serum by affinity-chromatography using the specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from part region of human AES protein

AES Polyclonal Antibody
ABP57720-02ml 0.2ml
EUR 496.8
Description: A polyclonal antibody for detection of AES from Human, Mouse, Rat. This AES antibody is for WB, ELISA. It is affinity-purified from rabbit serum by affinity-chromatography using the specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from part region of human AES protein

AES Polyclonal Antibody
ES10992-100ul 100ul
EUR 334.8
Description: A Rabbit Polyclonal antibody against AES from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, WB, ELISA

AES Polyclonal Antibody
ES10992-50ul 50ul
EUR 248.4
Description: A Rabbit Polyclonal antibody against AES from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, WB, ELISA

AES Polyclonal Antibody
E11-202046 100ug/100ul
EUR 225
Description: Available in various conjugation types.

Aes (untagged) - Mouse amino-terminal enhancer of split (Aes), (10ug)
MC208598 10 µg Ask for price

AES protein (His tag)
80R-1712 50 ug
EUR 366
Description: Purified recombinant Human AES protein

AES ELISA KIT|Human
EF004609 96 Tests
EUR 826.8

Rat AES shRNA Plasmid
20-abx985519
  • EUR 961.20
  • EUR 1345.20
  • 150 µg
  • 300 µg

Human AES shRNA Plasmid
20-abx950120
  • EUR 961.20
  • EUR 1345.20
  • 150 µg
  • 300 µg

Mouse AES shRNA Plasmid
20-abx970657
  • EUR 961.20
  • EUR 1345.20
  • 150 µg
  • 300 µg

Aes (GFP-tagged) - Mouse amino-terminal enhancer of split (Aes), (10ug)
MG217929 10 µg Ask for price

Aes (Myc-DDK-tagged) - Mouse amino-terminal enhancer of split (Aes)
MR217929 10 µg Ask for price

AES Recombinant Protein (Rat)
RP189452 100 ug Ask for price

OPPA00098-2UG - AES Protein
OPPA00098-2UG 2ug
EUR 70

AAP36553-100UG - AES Peptide
AAP36553-100UG 100ug
EUR 99

OACA07743-50UL - AES Antibody
OACA07743-50UL 50ul
EUR 189

OAAN02483-50UL - AES Antibody
OAAN02483-50UL 50ul
EUR 149

AES Recombinant Protein (Mouse)
RP114653 100 ug Ask for price

AES Recombinant Protein (Human)
RP036493 100 ug Ask for price

OACA07743-100UL - AES Antibody
OACA07743-100UL 100ul
EUR 230

OAPB00345-100UG - AES Antibody
OAPB00345-100UG 0.1mg
EUR 389

OAAN02483-100UL - AES Antibody
OAAN02483-100UL 100ul
EUR 249

OAAN02483-200UL - AES Antibody
OAAN02483-200UL 200ul
EUR 389

Rabbit Polyclonal AES Antibody
TA306253 100 µg Ask for price

Rabbit Polyclonal AES Antibody
TA306254 100 µg Ask for price

AES Rabbit Polyclonal Antibody
55355 100ul
EUR 439

Aes (untagged ORF) - Rat amino-terminal enhancer of split (Aes), (10 ug)
RN201994 10 µg Ask for price

AES (untagged)-Human amino-terminal enhancer of split (AES), transcript variant 2
SC119415 10 µg Ask for price

AES (untagged)-Human amino-terminal enhancer of split (AES), transcript variant 1
SC307835 10 µg Ask for price

AES (untagged)-Human amino-terminal enhancer of split (AES), transcript variant 3
SC307836 10 µg Ask for price

Aes (untagged) - Mouse amino-terminal enhancer of split (Aes), transcript variant 2
MC226221 10 µg Ask for price

AES Buffer 0.3M, pH 8.5
40120015-1 100 mL
EUR 36.33
Description: 2-Aminoethanesulfonic acid; 2-Aminoethylsulfonic acid; 2-Sulfoethylamine

AES Buffer 0.3M, pH 8.5
40120015-2 250 mL
EUR 64.02
Description: 2-Aminoethanesulfonic acid; 2-Aminoethylsulfonic acid; 2-Sulfoethylamine

AES Buffer 0.3M, pH 8.5
40120015-3 500 mL
EUR 84.96
Description: 2-Aminoethanesulfonic acid; 2-Aminoethylsulfonic acid; 2-Sulfoethylamine

AES Buffer 0.3M, pH 9.0
40120017-1 100 mL
EUR 36.33
Description: 2-Aminoethanesulfonic acid; 2-Aminoethylsulfonic acid; 2-Sulfoethylamine

AES Buffer 0.3M, pH 9.0
40120017-2 250 mL
EUR 64.02
Description: 2-Aminoethanesulfonic acid; 2-Aminoethylsulfonic acid; 2-Sulfoethylamine

AES Buffer 0.3M, pH 9.0
40120017-3 500 mL
EUR 84.96
Description: 2-Aminoethanesulfonic acid; 2-Aminoethylsulfonic acid; 2-Sulfoethylamine

AES Buffer 0.3M, pH 9.5
40120018-1 100 mL
EUR 36.33
Description: 2-Aminoethanesulfonic acid; 2-Aminoethylsulfonic acid; 2-Sulfoethylamine

AES Buffer 0.3M, pH 9.5
40120018-2 250 mL
EUR 64.02
Description: 2-Aminoethanesulfonic acid; 2-Aminoethylsulfonic acid; 2-Sulfoethylamine

AES Buffer 0.3M, pH 9.5
40120018-3 500 mL
EUR 90.14
Description: 2-Aminoethanesulfonic acid; 2-Aminoethylsulfonic acid; 2-Sulfoethylamine

Aes ORF Vector (Rat) (pORF)
ORF063152 1.0 ug DNA
EUR 607.2

AES (C-term) Rabbit pAb
E2612591 100ul
EUR 225
Description: Available in various conjugation types.

AES ORF Vector (Human) (pORF)
ORF012165 1.0 ug DNA
EUR 424.8

Aes ORF Vector (Mouse) (pORF)
ORF038219 1.0 ug DNA
EUR 607.2

[KO Validated] AES Rabbit pAb
A19944-100ul 100 ul
EUR 492

[KO Validated] AES Rabbit pAb
A19944-200ul 200 ul
EUR 685.2

[KO Validated] AES Rabbit pAb
A19944-20ul 20 ul
EUR 265.2

[KO Validated] AES Rabbit pAb
A19944-50ul 50 ul
EUR 344.4

Human AES knockout cell line
ABC-KH0360 1 vial Ask for price
Description: Human AES knockout cell line is HEK293/HeLa cell line, edited by CRISPR/Cas9 technology.

Human AES Protein Lysate 20ug
IHUAESPLLY20UG each
EUR 213
Description: Human AES Protein Lysate 20ug

Human AES knockdown cell line
ABC-KD0360 1 vial Ask for price
Description: Human AES knockdown cell line is engineered by our optimized transduction of the specific shRNA with lentivirus. Knockdown levels are determined via qRT-PCR. Gentaur offers generation of stable knockdown (RNAi) cell lines expressing shRNAs targeting genes of your interest.

Polyclonal AES Antibody (C-term)
APR14860G 0.1ml
EUR 580.8
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human AES (C-term). This antibody is tested and proven to work in the following applications:

Polyclonal AES Antibody (N-Term)
APR14862G 0.1 mg
EUR 580.8
Description: A polyclonal antibody raised in Goat that recognizes and binds to Human AES (N-Term). This antibody is tested and proven to work in the following applications:

AES (GFP-tagged) - Human amino-terminal enhancer of split (AES), transcript variant 2
RG212475 10 µg Ask for price

AES (GFP-tagged) - Human amino-terminal enhancer of split (AES), transcript variant 3
RG213043 10 µg Ask for price

AES (GFP-tagged) - Human amino-terminal enhancer of split (AES), transcript variant 1
RG217378 10 µg Ask for price

OCOA03889-20UG - AES Protein Lysate
OCOA03889-20UG 20ug
EUR 169

OCOA14729-20UG - AES Protein Lysate
OCOA14729-20UG 20ug
EUR 169

Aes (Myc-DDK-tagged ORF) - Rat amino-terminal enhancer of split (Aes), (10 ug)
RR201994 10 µg Ask for price

Lenti ORF clone of Aes (mGFP-tagged) - Mouse amino-terminal enhancer of split (Aes)
MR217929L4 10 µg Ask for price

AES (Myc-DDK-tagged)-Human amino-terminal enhancer of split (AES), transcript variant 3
RC213043 10 µg Ask for price

AES (Myc-DDK-tagged)-Human amino-terminal enhancer of split (AES), transcript variant 2
RC212475 10 µg Ask for price

AES (Myc-DDK-tagged)-Human amino-terminal enhancer of split (AES), transcript variant 1
RC217378 10 µg Ask for price

Aes (myc-DDK-tagged) - Mouse amino-terminal enhancer of split (Aes), transcript variant 2
MR228432 10 µg Ask for price

Compound 0120-0020
T131683-10mg 10mg Ask for price
Description: Compound 0120-0020

Compound 0120-0020
T131683-1g 1g Ask for price
Description: Compound 0120-0020

Compound 0120-0020
T131683-1mg 1mg Ask for price
Description: Compound 0120-0020

Compound 0120-0020
T131683-50mg 50mg Ask for price
Description: Compound 0120-0020

Compound 0120-0020
T131683-5mg 5mg Ask for price
Description: Compound 0120-0020

Compound 0120-0018
T131684-10mg 10mg Ask for price
Description: Compound 0120-0018

Compound 0120-0018
T131684-1g 1g Ask for price
Description: Compound 0120-0018

Compound 0120-0018
T131684-1mg 1mg Ask for price
Description: Compound 0120-0018

Compound 0120-0018
T131684-50mg 50mg Ask for price
Description: Compound 0120-0018

Compound 0120-0018
T131684-5mg 5mg Ask for price
Description: Compound 0120-0018

Compound N060-0120
T131220-10mg 10mg Ask for price
Description: Compound N060-0120

Compound N060-0120
T131220-1g 1g Ask for price
Description: Compound N060-0120

Compound N060-0120
T131220-1mg 1mg Ask for price
Description: Compound N060-0120

Compound N060-0120
T131220-50mg 50mg Ask for price
Description: Compound N060-0120

Compound N060-0120
T131220-5mg 5mg Ask for price
Description: Compound N060-0120

Lenti ORF clone of Aes (Myc-DDK-tagged) - Mouse amino-terminal enhancer of split (Aes)
MR217929L3 10 µg Ask for price

Aes sgRNA CRISPR Lentivector set (Rat)
K6789301 3 x 1.0 ug
EUR 406.8

OOCA00088-25T - Human AES Primer Pair
OOCA00088-25T 25Tests
EUR 229

Aes sgRNA CRISPR Lentivector set (Mouse)
K4753001 3 x 1.0 ug
EUR 406.8

AES sgRNA CRISPR Lentivector set (Human)
K0054101 3 x 1.0 ug
EUR 406.8

AAP32323-100UG - AES Peptide - middle region
AAP32323-100UG 100ug
EUR 99

Polyclonal AES antibody - C-terminal region
AMM08748G 0.1mg
EUR 580.8
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human AES - C-terminal region. This antibody is tested and proven to work in the following applications:

Polyclonal Aes Antibody - N-terminal region
AMM08749G 0.05mg
EUR 633.6
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human Aes - N-terminal region. This antibody is tested and proven to work in the following applications:

Polyclonal AES / Groucho Antibody (C-Terminus)
AMM08744G 0.05mg
EUR 580.8
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human AES / Groucho (C-Terminus). This antibody is tested and proven to work in the following applications:

Polyclonal AES / Groucho Antibody (N-Terminus)
AMM08745G 0.05mg
EUR 580.8
Description: A polyclonal antibody raised in Goat that recognizes and binds to Human AES / Groucho (N-Terminus). This antibody is tested and proven to work in the following applications:

ARP32323_P050-25UL - AES Antibody - middle region
ARP32323_P050-25UL 25ul
EUR 99

OPCA04809-1MG - AES Recombinant Protein (Human)
OPCA04809-1MG 1mg
EUR 1379

OPCA04809-20UG - AES Recombinant Protein (Human)
OPCA04809-20UG 20ug
EUR 218

OPCA04809-100UG - AES Recombinant Protein (Human)
OPCA04809-100UG 100ug
EUR 323

ARP32323_P050 - AES antibody - middle region (ARP32323_P050)
ARP32323_P050 100ul
EUR 389

Aes 3'UTR GFP Stable Cell Line
TU151481 1.0 ml Ask for price

AES 3'UTR GFP Stable Cell Line
TU050422 1.0 ml
EUR 1672.8

Aes 3'UTR GFP Stable Cell Line
TU250361 1.0 ml Ask for price

Lenti ORF clone of Aes (mGFP-tagged ORF) - Rat amino-terminal enhancer of split (Aes), (10 ug)
RR201994L4 10 µg Ask for price

AES Protein Vector (Rat) (pPM-C-HA)
PV252608 500 ng
EUR 723.6

AES Protein Vector (Rat) (pPB-C-His)
PV252606 500 ng
EUR 723.6

AES Protein Vector (Rat) (pPB-N-His)
PV252607 500 ng
EUR 723.6

AES Protein Vector (Rat) (pPM-C-His)
PV252609 500 ng
EUR 723.6

Lenti ORF particles, Aes (GFP-tagged) - Mouse amino-terminal enhancer of split (Aes), 200ul, >10^7 TU/mL
MR217929L4V 200 µl Ask for price

AES Protein Vector (Human) (pPM-C-HA)
PV048659 500 ng
EUR 577.2

AES Protein Vector (Mouse) (pPM-C-HA)
PV152876 500 ng
EUR 723.6

AES Protein Vector (Human) (pPB-C-His)
PV048657 500 ng
EUR 577.2

AES Protein Vector (Human) (pPB-N-His)
PV048658 500 ng
EUR 577.2

AES Protein Vector (Human) (pPM-C-His)
PV048660 500 ng
EUR 577.2

AES Protein Vector (Mouse) (pPB-C-His)
PV152874 500 ng
EUR 723.6

AES Protein Vector (Mouse) (pPB-N-His)
PV152875 500 ng
EUR 723.6

AES Protein Vector (Mouse) (pPM-C-His)
PV152877 500 ng
EUR 723.6

AES 3'UTR Luciferase Stable Cell Line
TU000422 1.0 ml
EUR 1672.8

Aes 3'UTR Luciferase Stable Cell Line
TU101481 1.0 ml Ask for price

Aes 3'UTR Luciferase Stable Cell Line
TU200361 1.0 ml Ask for price

AES Protein Vector (Human) (pPB-His-MBP)
PV320286 500 ng
EUR 577.2

AES Protein Vector (Human) (pPB-His-GST)
PV320287 500 ng
EUR 577.2

Lenti-ORF clone of AES (mGFP-tagged)-Human amino-terminal enhancer of split (AES), transcript variant 1
RC217378L4 10 µg Ask for price

Aes sgRNA CRISPR Lentivector (Rat) (Target 1)
K6789302 1.0 ug DNA
EUR 184.8

Aes sgRNA CRISPR Lentivector (Rat) (Target 2)
K6789303 1.0 ug DNA
EUR 184.8

Aes sgRNA CRISPR Lentivector (Rat) (Target 3)
K6789304 1.0 ug DNA
EUR 184.8

Human Amino-terminal enhancer of split (AES)
1-CSB-EP001405HU
  • EUR 456.00
  • EUR 256.80
  • EUR 1570.80
  • EUR 672.00
  • EUR 1047.60
  • EUR 314.40
  • 100ug
  • 10ug
  • 1MG
  • 200ug
  • 500ug
  • 50ug
Description: Recombinant Human Amino-terminal enhancer of split(AES) expressed in E.coli

Aes sgRNA CRISPR Lentivector (Mouse) (Target 1)
K4753002 1.0 ug DNA
EUR 184.8

Aes sgRNA CRISPR Lentivector (Mouse) (Target 2)
K4753003 1.0 ug DNA
EUR 184.8

Aes sgRNA CRISPR Lentivector (Mouse) (Target 3)
K4753004 1.0 ug DNA
EUR 184.8

AES sgRNA CRISPR Lentivector (Human) (Target 1)
K0054102 1.0 ug DNA
EUR 184.8

AES sgRNA CRISPR Lentivector (Human) (Target 2)
K0054103 1.0 ug DNA
EUR 184.8

AES sgRNA CRISPR Lentivector (Human) (Target 3)
K0054104 1.0 ug DNA
EUR 184.8

Amino-terminal enhancer of split (AES) Antibody
20-abx210483
  • EUR 493.20
  • EUR 360.00
  • 100 ul
  • 50 ul

Amino-terminal enhancer of split (AES) Antibody
20-abx210484
  • EUR 493.20
  • EUR 360.00
  • 100 ul
  • 50 ul

Amino-Terminal Enhancer of Split (AES) Antibody
20-abx225017
  • EUR 444.00
  • EUR 727.20
  • EUR 376.80
  • 100 ul
  • 200 ul
  • 50 ul

Monoclonal AES Antibody (monoclonal) (M02), Clone: 10
APR14861G 0.1mg
EUR 580.8
Description: A Monoclonal antibody against Human AES (monoclonal) (M02). The antibodies are raised in mouse and are from clone 10. This antibody is applicable in E

Amino-Terminal Enhancer of Split (AES) Antibody
abx027807-400ul 400 ul
EUR 627.6

Amino-Terminal Enhancer of Split (AES) Antibody
abx027807-80l 80 µl
EUR 343.2

Amino-Terminal Enhancer of Split (AES) Antibody
20-abx320627
  • EUR 360.00
  • EUR 292.80
  • 100 ul
  • 50 ul

Amino-Terminal Enhancer of Split (AES) Antibody
abx431308-200ul 200 ul
EUR 460.8

Amino-Terminal Enhancer of Split (AES) Antibody
20-abx007180
  • EUR 493.20
  • EUR 710.40
  • EUR 218.40
  • EUR 376.80
  • 100 ul
  • 200 ul
  • 20 ul
  • 50 ul

AES Antibody / Amino-terminal enhancer of split
RQ4533 100ug
EUR 356.15
Description: The AES gene is mapped to 19p13.3. The protein encoded by this gene is similar in sequence to the amino terminus of Drosophila enhancer of split groucho, a protein involved in neurogenesis during embryonic development. The encoded protein, which belongs to the groucho/TLE family of proteins, can function as a homooligomer or as a heteroologimer with other family members to dominantly repress the expression of other family member genes. Three transcript variants encoding different isoforms have been found for this gene.

Lenti ORF clone of Aes (Myc-DDK-tagged ORF) - Rat amino-terminal enhancer of split (Aes), (10 ug)
RR201994L3 10 µg Ask for price

Rabbit Anti Aes (C-Terminal) Polyclonal Antibody
CPBT-66226RA 50 µg
EUR 670.8

Rabbit Anti Aes (C-Terminal) Polyclonal Antibody
CPBT-66227RA 0.1 mg
EUR 696

AAP37710-100UG - Aes Peptide - C-terminal region
AAP37710-100UG 100ug
EUR 99

AAP32322-100UG - Aes Peptide - N-terminal region
AAP32322-100UG 100ug
EUR 99

Lenti ORF particles, Aes (GFP-tagged ORF) - Rat amino-terminal enhancer of split (Aes), 200ul, >10^7 TU/mL
RR201994L4V 200 µl Ask for price

OAEB02808-100UG - AES Antibody - N-terminal region
OAEB02808-100UG 100ug
EUR 349

ARP36553_T100-25UL - AES Antibody - C-terminal region
ARP36553_T100-25UL 25ul
EUR 99

ARP32322_P050-25UL - Aes Antibody - N-terminal region
ARP32322_P050-25UL 25ul
EUR 99

ARP37710_P050-25UL - Aes Antibody - C-terminal region
ARP37710_P050-25UL 25ul
EUR 99

Lenti ORF particles, Aes (Myc-DDK-tagged) - Mouse amino-terminal enhancer of split (Aes), 200ul, >10^7 TU/mL
MR217929L3V 200 µl Ask for price

Collectively, our findings not only offer systems biology approaches based drug target identification, but also provide the new clues for developing novel inhibitors for future breast cancer research.