NSCLC is one of the most common and most lethal malignancies throughout the world, and there is still a lack of sensitive diagnostic biomarkers. Identifying novel NSCLC biomarkers can help with the diagnosis and clinical decision-making.Identifying the differentially expressed circRNAs in three cases of NSCLC tissues by high-throughput circRNA microarray sequencing.
qRT-PCR was employed to detect the expression levels of hsa_circRNA_012515 in 80 cases of NSCLC tissues (tumor resection patients) and 60 cases of peripheral blood samples (chemotherapy patients), NSCLC cells and gefitinib-resistant NSCLC cell lines.
Then combining with clinical data, we discussed whether it was feasible to use hsa_circRNA_012515 as the diagnostic and prognostic biomarker for NSCLC.In the cancerous tissues from NSCLC patients, NSCLC cells and gefitinib-resistant cell lines, the average expressions of hsa_circRNA_012515 increased significantly (P<0.01). Patients of stage III-IV, with lymph node metastases, had an overexpression of hsa_circRNA_012515.
High expression of hsa_circRNA_012515 was associated with lower OS and shorter PFS, and it is closely related to the prognosis of the patients. Bioinformatic analysis indicated that hsa_circRNA_012515 interacted with 5 miRNAs.
HZ-PEG-HZ |
abx085131-34kDa1g |
Abbexa |
3.4 kDa; 1 g |
EUR 370 |
- Shipped within 5-10 working days.
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HZ-PEG-HZ |
abx085131-5kDa1g |
Abbexa |
5 kDa; 1 g |
EUR 370 |
- Shipped within 5-10 working days.
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HZ-PEG-HZ,10K |
33-HO019019-10K |
Biochempeg |
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Description: A high purity chemical with various applications in medical research, drug-release, nanotechnology and new materials research, cell culture. In the study of ligand, polypeptide synthesis support, a graft polymer compounds, new materials, and polyethylene glycol-modified functional coatings and other aspects of the active compound. |
HZ-PEG-HZ,1K |
33-HO019019-1K |
Biochempeg |
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Description: A high purity chemical with various applications in medical research, drug-release, nanotechnology and new materials research, cell culture. In the study of ligand, polypeptide synthesis support, a graft polymer compounds, new materials, and polyethylene glycol-modified functional coatings and other aspects of the active compound. |
HZ-PEG-HZ,20K |
33-HO019019-20K |
Biochempeg |
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Description: A high purity chemical with various applications in medical research, drug-release, nanotechnology and new materials research, cell culture. In the study of ligand, polypeptide synthesis support, a graft polymer compounds, new materials, and polyethylene glycol-modified functional coatings and other aspects of the active compound. |
HZ-PEG-HZ,2K |
33-HO019019-2K |
Biochempeg |
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Description: A high purity chemical with various applications in medical research, drug-release, nanotechnology and new materials research, cell culture. In the study of ligand, polypeptide synthesis support, a graft polymer compounds, new materials, and polyethylene glycol-modified functional coatings and other aspects of the active compound. |
HZ-PEG-HZ,3.4K |
33-HO019019-3.4K |
Biochempeg |
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Description: A high purity chemical with various applications in medical research, drug-release, nanotechnology and new materials research, cell culture. In the study of ligand, polypeptide synthesis support, a graft polymer compounds, new materials, and polyethylene glycol-modified functional coatings and other aspects of the active compound. |
HZ-PEG-HZ,5K |
33-HO019019-5K |
Biochempeg |
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Description: A high purity chemical with various applications in medical research, drug-release, nanotechnology and new materials research, cell culture. In the study of ligand, polypeptide synthesis support, a graft polymer compounds, new materials, and polyethylene glycol-modified functional coatings and other aspects of the active compound. |
mPEG-HZ |
abx085015-10kDa1g |
Abbexa |
10 kDa; 1 g |
EUR 356 |
- Shipped within 5-10 working days.
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mPEG-HZ |
abx085015-1kDa1g |
Abbexa |
1 kDa; 1 g |
EUR 328 |
- Shipped within 5-10 working days.
|
mPEG-HZ |
abx085015-40kDa1g |
Abbexa |
40 kDa; 1 g |
EUR 356 |
- Shipped within 5-10 working days.
|
HZ-1157 |
A8898-25 |
ApexBio |
25 mg |
EUR 1442 |
Description: HZ-1157 is a potent hepatitis C virus (HCV) inhibitor toward HCV NS3/4A protease with IC50 value of 1.0 ?mol/L [1]. |
HZ-1157 |
A8898-5 |
ApexBio |
5 mg |
EUR 456 |
Description: HZ-1157 is a potent hepatitis C virus (HCV) inhibitor toward HCV NS3/4A protease with IC50 value of 1.0 ?mol/L [1]. |
hsa-miR-1264 Primers |
MPH01088 |
ABM |
150 ul / 10 uM |
EUR 121 |
SH-PEG-HZ |
abx085245-10kDa1g |
Abbexa |
10 kDa; 1 g |
EUR 718 |
- Shipped within 5-10 working days.
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SH-PEG-HZ |
abx085245-2kDa1g |
Abbexa |
2 kDa; 1 g |
EUR 718 |
- Shipped within 5-10 working days.
|
SH-PEG-HZ |
abx085245-5kDa5g |
Abbexa |
5 kDa; 5 g |
EUR 1817 |
- Shipped within 5-10 working days.
|
Mal-PEG-HZ |
abx085354-10kDa1g |
Abbexa |
10 kDa; 1 g |
EUR 428 |
- Shipped within 5-10 working days.
|
Mal-PEG-HZ |
abx085354-1kDa1g |
Abbexa |
1 kDa; 1 g |
EUR 428 |
- Shipped within 5-10 working days.
|
Mal-PEG-HZ |
abx085354-2kDa1g |
Abbexa |
2 kDa; 1 g |
EUR 458 |
- Shipped within 5-10 working days.
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Mal-PEG-HZ |
abx085354-5kDa1g |
Abbexa |
5 kDa; 1 g |
EUR 458 |
- Shipped within 5-10 working days.
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mmu-miR-1264-3p Primers |
MPM00054 |
ABM |
150 ul / 10 uM |
EUR 121 |
mmu-miR-1264-5p Primers |
MPM00055 |
ABM |
150 ul / 10 uM |
EUR 121 |
hsa-miR-1264 miRNA Inhibitor |
MIH01167 |
ABM |
2 x 5.0 nmol |
EUR 176 |
hsa-miR-1264 miRNA Antagomir |
MNH01167 |
ABM |
2 x 5.0 nmol |
EUR 329 |
SH-PEG-HZ,10K |
HE003019-10K-1g1050 |
Biochempeg |
1g1050 |
EUR 482 |
Description: A high purity chemical with various applications in medical research, drug-release, nanotechnology and new materials research, cell culture. In the study of ligand, polypeptide synthesis support, a graft polymer compounds, new materials, and polyethylene glycol-modified functional coatings and other aspects of the active compound. |
SH-PEG-HZ,1K |
HE003019-1K-1g1050 |
Biochempeg |
1g1050 |
EUR 482 |
Description: A high purity chemical with various applications in medical research, drug-release, nanotechnology and new materials research, cell culture. In the study of ligand, polypeptide synthesis support, a graft polymer compounds, new materials, and polyethylene glycol-modified functional coatings and other aspects of the active compound. |
SH-PEG-HZ,2K |
HE003019-2K-1g1050 |
Biochempeg |
1g1050 |
EUR 482 |
Description: A high purity chemical with various applications in medical research, drug-release, nanotechnology and new materials research, cell culture. In the study of ligand, polypeptide synthesis support, a graft polymer compounds, new materials, and polyethylene glycol-modified functional coatings and other aspects of the active compound. |
SH-PEG-HZ,3.4K |
HE003019-3.4K-1g1050 |
Biochempeg |
1g1050 |
EUR 482 |
Description: A high purity chemical with various applications in medical research, drug-release, nanotechnology and new materials research, cell culture. In the study of ligand, polypeptide synthesis support, a graft polymer compounds, new materials, and polyethylene glycol-modified functional coatings and other aspects of the active compound. |
SH-PEG-HZ,5K |
HE003019-5K-1g1050 |
Biochempeg |
1g1050 |
EUR 482 |
Description: A high purity chemical with various applications in medical research, drug-release, nanotechnology and new materials research, cell culture. In the study of ligand, polypeptide synthesis support, a graft polymer compounds, new materials, and polyethylene glycol-modified functional coatings and other aspects of the active compound. |
SH-PEG-HZ,6K |
HE003019-6K-1g1050 |
Biochempeg |
1g1050 |
EUR 482 |
Description: A high purity chemical with various applications in medical research, drug-release, nanotechnology and new materials research, cell culture. In the study of ligand, polypeptide synthesis support, a graft polymer compounds, new materials, and polyethylene glycol-modified functional coatings and other aspects of the active compound. |
Mal-PEG-HZ,10K |
33-HE022019-10K |
Biochempeg |
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Description: A high purity chemical with various applications in medical research, drug-release, nanotechnology and new materials research, cell culture. In the study of ligand, polypeptide synthesis support, a graft polymer compounds, new materials, and polyethylene glycol-modified functional coatings and other aspects of the active compound. |
Mal-PEG-HZ,1K |
33-HE022019-1K |
Biochempeg |
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Description: A high purity chemical with various applications in medical research, drug-release, nanotechnology and new materials research, cell culture. In the study of ligand, polypeptide synthesis support, a graft polymer compounds, new materials, and polyethylene glycol-modified functional coatings and other aspects of the active compound. |
Mal-PEG-HZ,20K |
33-HE022019-20K |
Biochempeg |
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Description: A high purity chemical with various applications in medical research, drug-release, nanotechnology and new materials research, cell culture. In the study of ligand, polypeptide synthesis support, a graft polymer compounds, new materials, and polyethylene glycol-modified functional coatings and other aspects of the active compound. |
Mal-PEG-HZ,2K |
33-HE022019-2K |
Biochempeg |
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Description: A high purity chemical with various applications in medical research, drug-release, nanotechnology and new materials research, cell culture. In the study of ligand, polypeptide synthesis support, a graft polymer compounds, new materials, and polyethylene glycol-modified functional coatings and other aspects of the active compound. |
Mal-PEG-HZ,3.4K |
33-HE022019-3.4K |
Biochempeg |
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Description: A high purity chemical with various applications in medical research, drug-release, nanotechnology and new materials research, cell culture. In the study of ligand, polypeptide synthesis support, a graft polymer compounds, new materials, and polyethylene glycol-modified functional coatings and other aspects of the active compound. |
Mal-PEG-HZ,5K |
33-HE022019-5K |
Biochempeg |
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Description: A high purity chemical with various applications in medical research, drug-release, nanotechnology and new materials research, cell culture. In the study of ligand, polypeptide synthesis support, a graft polymer compounds, new materials, and polyethylene glycol-modified functional coatings and other aspects of the active compound. |
mmu-miR-1264-3p miRNA Inhibitor |
MIM01113 |
ABM |
2 x 5.0 nmol |
EUR 176 |
mmu-miR-1264-5p miRNA Inhibitor |
MIM01114 |
ABM |
2 x 5.0 nmol |
EUR 176 |
mmu-miR-1264-3p miRNA Antagomir |
MNM01113 |
ABM |
2 x 5.0 nmol |
EUR 329 |
mmu-miR-1264-5p miRNA Antagomir |
MNM01114 |
ABM |
2 x 5.0 nmol |
EUR 329 |
Human pre-microRNA Expression Construct Lenti-miR-1264 |
PMIRH1264PA-1 |
SBI |
Bacterial Streak |
EUR 684 |
|
Salicyclic Acid-HRP |
80-1264 |
Fitzgerald |
500 ul |
EUR 549 |
Description: Salicyclic Acid Conjugate for use in immunoassays |
MAT1A protein (His tag) |
80R-1264 |
Fitzgerald |
50 ug |
EUR 457 |
Description: Purified recombinant Human MAT1A protein |
SYT2 Blocking Peptide |
33R-1264 |
Fitzgerald |
100 ug |
EUR 180 |
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of DAG1 antibody, catalog no. 70R-6688 |
Goat anti Human kappa chain (biotin) |
43R-1264 |
Fitzgerald |
500 ug |
EUR 440 |
Description: Goat anti Human kappa chain secondary antibody (biotin) |
HSPA1L antibody |
10R-1264 |
Fitzgerald |
100 ug |
EUR 512 |
Description: Mouse monoclonal HSPA1L antibody |
NGAL antibody |
10-1264 |
Fitzgerald |
500 ug |
EUR 349 |
Description: Mouse monoclonal NGAL antibody |
TG1 Phage Display Electrocompetent Cells - 6x100µl |
1264-24 |
Intact Genomics |
6/PK |
EUR 300 |
TG1 Phage Display Electrocompetent Cells - 6x50µl |
1264-48 |
Intact Genomics |
6/PK |
EUR 497 |
COMT protein |
30R-1264 |
Fitzgerald |
100 ug |
EUR 586 |
Description: Purified recombinant Human COMT protein |
Mouse Salivary Gland virus protein |
30-1264 |
Fitzgerald |
1 mg |
EUR 241 |
Description: Purified native Mouse Salivary Gland virus protein |
SETD2 antibody |
20R-1264 |
Fitzgerald |
100 ug |
EUR 377 |
Description: Rabbit polyclonal SETD2 antibody |
CD61 antibody (PE) |
61R-1264 |
Fitzgerald |
100 ug |
EUR 349 |
Description: Armenian Hamster monoclonal CD61 antibody (PE) |
CTNNB1 antibody (FITC) |
60R-1264 |
Fitzgerald |
100 ug |
EUR 327 |
Description: Rabbit polyclonal CTNNB1 antibody (FITC) |
Tropomyosin 2 antibody |
70R-1264 |
Fitzgerald |
100 ug |
EUR 377 |
Description: Rabbit polyclonal Tropomyosin 2 antibody |
Anti-IGF1R (Dalotuzumab)-MC-MMAF ADC |
ADC-W-1264 |
Creative Biolabs |
1mg |
Ask for price |
Description: This ADC product is comprised of an anti-IGF1R monoclonal antibody conjugated via a MC linker to MMAF |
Anti-Calponin-1 Antibody Clone CALP, Unconjugated-100ug |
1264-MSM1-P1 |
EnQuireBio |
100ug |
EUR 428 |
Anti-Calponin-1 Antibody Clone SPM169, Unconjugated-100ug |
1264-MSM1X-P1 |
EnQuireBio |
100ug |
EUR 428 |
Anti-Calponin-1 Antibody Clone CNN1/832, Unconjugated-100ug |
1264-MSM2-P1 |
EnQuireBio |
100ug |
EUR 428 |
Anti-Calponin-1 Antibody Clone CNN1/832 + CALP, Unconjugated-100ug |
1264-MSM3-P1 |
EnQuireBio |
100ug |
EUR 428 |
Anti-Calponin-1 Antibody Clone rCNN1/832, Unconjugated-20ug |
1264-MSM6-P0 |
EnQuireBio |
20ug |
EUR 233 |
Anti-Calponin-1 Antibody Clone rCNN1/832, Unconjugated-100ug |
1264-MSM6-P1 |
EnQuireBio |
100ug |
EUR 428 |
Anti-Calponin-1 Antibody Clone CNN1/1408R, Unconjugated-20ug |
1264-RBM4-P0 |
EnQuireBio |
20ug |
EUR 233 |
Anti-Calponin-1 Antibody Clone CNN1/1408R, Unconjugated-100ug |
1264-RBM4-P1 |
EnQuireBio |
100ug |
EUR 428 |
Human Angiopoietin 4,ANG-4 ELISA Kit |
201-12-1264 |
SunredBio |
96 tests |
EUR 440 |
- This Angiopoietin 4 ELISA kit is validated to work with samples from whole blood, serum, plasma and cell culture supernatant.
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Description: A quantitative ELISA kit for measuring Human in samples from biological fluids. |
This finding may shed new light on the subsequent studies on the working mechanism and functions.Our study showed that hsa_circRNA_012515 may be a novel biomarker candidate for NSCLC. However, further studies are needed to ascertain the working mechanism of hsa_circRNA_012515 in the occurrence and development of NSCLC.