hsa_circRNA_012515 Is Highly Expressed in NSCLC Patients and Affects Its Prognosis.

NSCLC is one of the most common and most lethal malignancies throughout the world, and there is still a lack of sensitive diagnostic biomarkers. Identifying novel NSCLC biomarkers can help with the diagnosis and clinical decision-making.Identifying the differentially expressed circRNAs in three cases of NSCLC tissues by high-throughput circRNA microarray sequencing.

qRT-PCR was employed to detect the expression levels of hsa_circRNA_012515 in 80 cases of NSCLC tissues (tumor resection patients) and 60 cases of peripheral blood samples (chemotherapy patients), NSCLC cells and gefitinib-resistant NSCLC cell lines.

Then combining with clinical data, we discussed whether it was feasible to use hsa_circRNA_012515 as the diagnostic and prognostic biomarker for NSCLC.In the cancerous tissues from NSCLC patients, NSCLC cells and gefitinib-resistant cell lines, the average expressions of hsa_circRNA_012515 increased significantly (P<0.01). Patients of stage III-IV, with lymph node metastases, had an overexpression of hsa_circRNA_012515.

High expression of hsa_circRNA_012515 was associated with lower OS and shorter PFS, and it is closely related to the prognosis of the patients. Bioinformatic analysis indicated that hsa_circRNA_012515 interacted with 5 miRNAs.

HZ-PEG-HZ,10K
33-HO019019-10K	Biochempeg	EUR 225.00 EUR 573.00	1g 5g
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HZ-PEG-HZ,1K
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HZ-PEG-HZ,20K
33-HO019019-20K	Biochempeg	EUR 225.00 EUR 573.00	1g 5g
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HZ-PEG-HZ,2K
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HZ-PEG-HZ,3.4K
33-HO019019-3.4K	Biochempeg	EUR 201.00 EUR 503.00	1g 5g
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HZ-PEG-HZ,5K
33-HO019019-5K	Biochempeg	EUR 201.00 EUR 503.00	1g 5g
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mPEG-HZ
abx085015-10kDa1g	Abbexa	10 kDa; 1 g	EUR 356

mPEG-HZ
abx085015-1kDa1g	Abbexa	1 kDa; 1 g	EUR 328

mPEG-HZ
abx085015-40kDa1g	Abbexa	40 kDa; 1 g	EUR 356

HZ-1157
A8898-25	ApexBio	25 mg	EUR 1442
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HZ-1157
A8898-5	ApexBio	5 mg	EUR 456
Description: HZ-1157 is a potent hepatitis C virus (HCV) inhibitor toward HCV NS3/4A protease with IC50 value of 1.0 ?mol/L [1].

hsa-miR-1264 Primers
MPH01088	ABM	150 ul / 10 uM	EUR 121

SH-PEG-HZ
abx085245-10kDa1g	Abbexa	10 kDa; 1 g	EUR 718

SH-PEG-HZ
abx085245-2kDa1g	Abbexa	2 kDa; 1 g	EUR 718

SH-PEG-HZ
abx085245-5kDa5g	Abbexa	5 kDa; 5 g	EUR 1817

Mal-PEG-HZ
abx085354-10kDa1g	Abbexa	10 kDa; 1 g	EUR 428

Mal-PEG-HZ
abx085354-1kDa1g	Abbexa	1 kDa; 1 g	EUR 428

Mal-PEG-HZ
abx085354-2kDa1g	Abbexa	2 kDa; 1 g	EUR 458

Mal-PEG-HZ
abx085354-5kDa1g	Abbexa	5 kDa; 1 g	EUR 458

hsa-miR-1264 miRNA Inhibitor
MIH01167	ABM	2 x 5.0 nmol	EUR 176

hsa-miR-1264 miRNA Antagomir
MNH01167	ABM	2 x 5.0 nmol	EUR 329

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MPM00054	ABM	150 ul / 10 uM	EUR 121

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MPM00055	ABM	150 ul / 10 uM	EUR 121

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Mal-PEG-HZ,20K
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mmu-miR-1264-3p miRNA Inhibitor
MIM01113	ABM	2 x 5.0 nmol	EUR 176

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MIM01114	ABM	2 x 5.0 nmol	EUR 176

mmu-miR-1264-3p miRNA Antagomir
MNM01113	ABM	2 x 5.0 nmol	EUR 329

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MNM01114	ABM	2 x 5.0 nmol	EUR 329

Human pre-microRNA Expression Construct Lenti-miR-1264
PMIRH1264PA-1	SBI	Bacterial Streak	EUR 684

TG1 Phage Display Electrocompetent Cells - 6x100µl
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60R-1264	Fitzgerald	100 ug	EUR 327
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20R-1264	Fitzgerald	100 ug	EUR 377
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70R-1264	Fitzgerald	100 ug	EUR 377
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80-1264	Fitzgerald	500 ul	EUR 549
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30R-1264	Fitzgerald	100 ug	EUR 586
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201-12-1264	SunredBio	96 tests	EUR 440
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Anti-IGF1R (Dalotuzumab)-MC-MMAF ADC
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1264-MSM1-P1	EnQuireBio	100ug	EUR 428

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1264-MSM6-P1	EnQuireBio	100ug	EUR 428

Anti-Calponin-1 Antibody Clone CNN1/1408R, Unconjugated-20ug
1264-RBM4-P0	EnQuireBio	20ug	EUR 233

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1264-RBM4-P1	EnQuireBio	100ug	EUR 428

This finding may shed new light on the subsequent studies on the working mechanism and functions.Our study showed that hsa_circRNA_012515 may be a novel biomarker candidate for NSCLC. However, further studies are needed to ascertain the working mechanism of hsa_circRNA_012515 in the occurrence and development of NSCLC.